SD-619

SD-619 is a naturemarineprotein component similar to humanmethionine aminoprpttidase 2 complex with TNP-470, which is a modified protein from nature angiogenesis inhibitor fumagillin, target the enzyme methionine aminopeptidase type II (MetAP2, or p67). Which is related many types of cancer,metabolic disorders.

Reference

Zhang, Y., Yeh, J. R., Mara, A., Ju, R., Hines, J. F., Cirone, P., ... & Crews, C. M. (2006). A chemical and genetic approach to the mode of action of Fumagillin. Chemistry & biology, 13(9), 1001-1009.
Selvakumar, P., Lakshmikuttyamma, A., Dimmock, J. R., & Sharma, R. K. (2006). Methionine aminopeptidase 2 and cancer. Biochimica et Biophysica Acta (BBA)-Reviews on Cancer, 1765(2), 148-154.
Moon, D. O. (2024). MetAP2 as a Therapeutic Target for Obesity and Type 2 Diabetes: Structural Insights, Mechanistic Roles, and Inhibitor Development. Biomolecules, 14(12), 1572.