SD-699

SD-699 is a marine-derived protein contain chondroitin sulfate, glucosamine sulfate, and undenatured type II collagen. Both of the above protein could offer different kinds of function for human: anti-inflammatory activity, cell activities and adjustment, It has also been shown to have anti-aging properties [201] and the ability to improve symptoms of bladder inflammation and interstitial cystitis

Module 1: Cancer Microenvironment

• TGF-β promotes angiogenesis, immune evasion, and tumor metastasis.

• SD-619 inhibits MetAP2, disrupts VEG/EMT signaling.

• Marker proteins: Smad2/3, PD-LI, VEGF, BAMBI.

Module 2: Neurodegeneration

• KLK6 activates inflammatory pathways, accelerates neurodegeneration

• TGF-B1/Smad2/3 involved in Tau clearance and microglia regulation

• Biomarkers: Tau, a-synuclein, GFAP, P IL-6

Reference:

Sheikh, A. M., Yano, S., Tabassum, S., Mitaki, S., Michikawa, M., & Nagai, A. (2023). Alzheimer’s amyloid β peptide induces angiogenesis in an Alzheimer’s disease model mouse through placental growth factor and angiopoietin 2 expressions. International Journal of Molecular Sciences, 24(5), 4510.

Module 3: Regenerative Medicine

• TGF-β promotes angiogenesis, immune evasion, tumor metastasis .

• SD-619 inhibits TGF-β activity, suppresses fibrosis.

• Core proteins: ALK5, Smad2/3, OCT4, BMP2, Id1.

Reference:

Cancer immunotherapy is a form of regenerative medicine
The process of activating, replacing, engineering or regenerating human cells, tissues or organs to restore or establish normal function refers to regenerative medicine. Cancer immunotherapy activates, replaces, engineers or regenerates the immune system in order to fight cancer. In fact, it is the most frequently used and marketed form of regenerative medicine.

Reference

  • Shen Q, Guo Y, Wang K, Zhang C, Ma Y. A Review of Chondroitin Sulfate’s Preparation, Properties, Functions, and Applications. Molecules. 2023; 28(20):7093. https://doi.org/10.3390/molecules28207093